papers – brineylab

2020

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Rogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ramirez S, Ricketts J, Ricciardi MJ, Rawlings SA, Wu NC, Yuan M, Smith DM, Nemazee D, Teijaro JR, Voss JE, Wilson IA, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR
Science. 2020 Jun 15. doi: 10.1126/science.abc75203

Benchmarking immunoinformatic tools for the analysis of antibody repertoire sequences

Smakaj E, Babrak L, Ohlin M, Shugay M, Briney B, Tosoni D, Galli C, Grobelsek V, D’Angelo I, Olson B, Reddy S, Greiff V, Trück J, Marquez S, Lees W, Miho E
Bioinformatics. 2020 Mar 1. doi: 10.1093/bioinformatics/btz845

Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing

Joyce C, Burton DR, Briney B
Scientific Reports. 2020 Jan 24. doi: 10.1038/s41598-020-57764-7

2019

Rapid germinal center and antibody responses in non-human primates after a single nanoparticle vaccine immunization

Havenar-Daughton C, Carnathan DG, Boopathy AV, Upadhyay AA, Murrell B, Reiss SM, Enemuo CA, Gebru EH, Choe Y, Dhadvai P, Viviano F, Kaushik K, Bhiman JN, Briney B, Burton DR, Bosinger SE, Schief WR, Irvine DJ, Silvestri G, Crotty S
Cell Reports. 2019 Nov 12. doi: 10.1016/j.celrep.2019.10.008

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science. 2019 Oct 31. doi: 10.1126/science.aax4380

Advancing computational biology and bioinformatics research through open innovation competitions

Blasco A, Endres MG, Sergeev RA, Jonchhe A, Macaluso NJM, Narayan R, Natoli T, Paik JH, Briney B, Wu C, Su AI, Subramanian A, Lakhani KR
PLoS One. 2019 Sep 27. doi: 10.1371/journal.pone.0222165

Rapid and focused maturation of a VRC01-class HIV broadly neutralizing antibody lineage involves both binding and accommodation of the N276-glycan

Umotoy J, Bagaya BS, Joyce C, Schiffner T, Menis S, Saye-Francisco KL, Biddle T, Mohan S, Vollbrecht T, Kalyuzhniy O, Madzorera S, Kitchin D, Lambson B, Nonyane M, Kilembe W; IAVI Protocol C Investigators; IAVI African HIV Research Network, Poignard P, Schief WR, Burton DR, Murrell B, Moore PL, Briney B, Sok D, Landais E
Immunity. 2019 Jul 16. doi: 10.1016/j.immuni.2019.06.004

Commonality despite exceptional diversity in the baseline human antibody repertoire

Briney B, Inderbitzin A, Joyce C, Burton DR
Nature. 2019 Jan 21. doi: 10.1038/s41586-019-0879-y

Reprogramming the antigen specificity of B cells using genome-editing technologies

Voss JE, Gonzalez-Martin A, Andrabi R, Fuller RP, Murrell B, McCoy LE, Porter K, Huang D, Li W, Sok D, Le K, Briney B, Chateau M, Rogers G, Hangartner L, Feeney AJ, Nemazee D, Cannon P, Burton DR
eLife. 2019 Jan 17. doi: 10.7554/eLife.42995

2018

Massively scalable genetic analysis of antibody repertoires

Briney B, Burton DR
bioRxiv. 2018 Oct 19. doi: 10.1101/447813

2017

HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage

Landais E, Murrell B, Briney B, Murrell S, Rantalainen K, Berndsen ZT, Ramos A, Wickramasinghe L, Smith ML, Eren K, de Val N, Wu M, Cappelletti A, Umotoy J, Lie Y, Wrin T, Algate P, Chan-Hui PY, Karita E; IAVI Protocol C Investigators; IAVI African HIV Research Network, Ward AB, Wilson IA, Burton DR, Smith D, Pond SLK, Poignard P
Immunity. 2017 Nov 21;47(5):990-1003.e9. doi: 10.1016/j.immuni.2017.11.002

Glycans function as anchors for antibodies and help drive HIV broadly neutralizing antibody development

Andrabi R, Su CY, Liang CH, Shivatare SS, Briney B, Voss JE, Nawazi SK, Wu CY, Wong CH, Burton DR
Immunity. 2017 Sep 19;47(3):524-537.e3. doi: 10.1016/j.immuni.2017.08.006

Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors

Rogers TF*, Goodwin EC*, Briney B, Sok D, Beutler N, Strubel A, Nedellec R, Le K, Brown ME, Burton DR, Walker LM
Sci Immunol. 2017 Aug 18;2(14). pii: eaan6809. doi: 10.1126/sciimmunol.aan6809

Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

Magnani DM*, Rogers TF*, Beutler N, Ricciardi MJ, Bailey VK, Gonzalez-Nieto L, Briney B, Sok D, Le K, Strubel A, Gutman MJ, Pedreño-Lopez N, Grubaugh ND, Silveira CGT, Maxwell HS, Domingues A, Martins MA, Lee DE, Okwuazi EE, Jean S, Strobert EA, Chahroudi A,, Silvestri G, Vanderford TH, Kallas EG, Desrosiers RC, Bonaldo MC, Whitehead SS, Burton DR, Watkins DI
Sci Transl Med. 2017 Oct 4;9(410). pii: eaan8184. doi: 10.1126/scitranslmed.aan8184

2016

Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies

Briney B*, Sok D*, Jardine JG*, Kulp DW*, Skog P*, Menis S, Jacak R, Kalyuzhniy O, de Val N, Sesterhenn F, Le KM, Ramos A, Jones M, Saye-Francisco KL, Blane TR, Spencer S, Georgeson E, Hu X, Ozorowski G, Adachi Y, Kubitz M, Sarkar A, Wilson IA, Ward AB, Nemazee D, Burton DR, Schief WR
Cell. 2016 Sep 8;166(6):1459-1470.e11. doi: 10.1016/j.cell.2016.08.005

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

Sok D*, Briney B*, Jardine JG*, Kulp DW*, Menis S*, Pauthner M, Wood A, Lee EC, Le KM, Jones M, Ramos A, Kalyuzhniy O, Adachi Y, Kubitz M, MacPherson S, Bradley A, Friedrich GA, Schief WR, Burton DR
Science. 2016 Sep 30;353(6307):1557-1560. doi: 10.1126/science.aah3945

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

Jardine JG*, Kulp DW*, Havenar-Daughton C*, Sarkar A*, Briney B*, Sok D*, Sesterhenn F, Ereño-Orbea J, Kalyuzhniy O, Deresa I, Hu X, Spencer S, Jones M, Georgeson E, Adachi Y, Kubitz M, deCamp AC, Julien JP, Wilson IA, Burton DR, Crotty S, Schief WR
Science. 2016 Mar 25;351(6280):1458-63. doi: 10.1126/science.aad9195

Clonify: unseeded antibody lineage assignment from next-generation sequencing data

Briney B, Le K,, Zhu J, Burton DR
Sci Rep. 2016 Apr 22;6:23901. doi: 10.1038/srep23901

Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design

Jardine JG*, Sok D*, Julien JP*, Briney B*, Sarkar A*, Liang CH, Scherer EA, Henry Dunand CJ, Adachi Y, Diwanji D, Hsueh J, Jones M, Kalyuzhniy O, Kubitz M, Spencer S, Pauthner M, Saye-Francisco KL, Sesterhenn F, Wilson PC, Galloway DM, Stanfield RL, Wilson IA, Burton DR, Schief WR
PLoS Pathog. 2016 Aug 25;12(8):e1005815. doi: 10.1371/journal.ppat.1005815

A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 ninding and its camouflaging glycans

Sok D, Pauthner M, Briney B, Lee JH, Saye-Francisco KL, Hsueh J, Ramos A, Le KM, Jones M, Jardine JG, Bastidas R, Sarkar A, Liang CH, Shivatare SS, Wu CY, Schief WR, Wong CH, Wilson IA, Ward AB, Zhu J, Poignard P, Burton DR
Immunity. 2016 Jul 19;45(1):31-45. doi: 10.1016/j.immuni.2016.06.026

Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer

Havenar-Daughton C, Carnathan DG, Torrents de la Peña A, Pauthner M, Briney B, Reiss SM, Wood JS, Kaushik K, van Gils MJ, Rosales SL, van der Woude P, Locci M, Le KM, de Taeye SW, Sok D, Mohammed AUR, Huang J, Gumber S, Garcia A, Kasturi SP, Pulendran B, Moore JP0, Ahmed R, Seumois G, Burton DR, Sanders RW, Silvestri G, Crotty S
Cell Rep. 2016 Nov 22;17(9):2195-2209. doi: 10.1016/j.celrep.2016.10.085